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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: Influence of salt solution on the physicochemical properties and in vitro/ in vivo expression of mRNA/LNP

Fig. 1

Influence of mRNA aqueous solution on mRNA/LNP. (A) Schematic of the LNP preparation method with different mRNA aqueous solutions. (B) Transfection efficiency of mRNA/LNP in DC2.4 cells and AML12 cells. (C) Correlation between mRNA aqueous solutions, physicochemical properties, and transfection ability. The correlation of pH and size (D), pH and EE (E), concentration of acid solution and size (F), Zeta potential and EE (G). (H) The impact of mRNA aqueous solution pH on the transfection of LNPs in DC2.4 cells and AML12 cells. (I) The effect of different acid type of mRNA aqueous solutions on the transfection of LNPs in DC2.4 cells and AML12 cells. Data were presented as mean ± SD. *p < 0.05, **p < 0.01

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Journal of Nanobiotechnology

ISSN: 1477-3155

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