Fig. 6

DAC + 5-FU@HFn induced pyroptosis and activated antitumor immunity in CML mice. (A) Western blot analysis of GSDME-N and cleaved caspase-3 (C-Casp3) protein expression in the bone marrow cells of CML mice. (B) IL-1β (pg/mL) and (C) IL-6 (pg/mL) levels in the blood of CML mice in different groups were measured. (D) (F) The percentages of CD8⁺ T lymphocyte subsets in the peripheral blood of CML mice were analyzed by flow cytometry (FCM). (E) (G) The percentage of mature dendritic cells (DCs) analyzed by FCM in CML mouse bone marrow cells. (H) Kaplan‒Meier survival curves for CML mice. All the data are presented as the means ± SDs. * P < 0.05, ** P < 0.01