Fig. 7

Distribution and biosafety of 5-FU@HFn in vivo. (A) Bioluminescence imaging revealed CML cell infiltration in the CML-NSG mouse model established with luc-K562/G01 cells. (B) Fluorescence images of major organs anatomized from CML-NSG mice 12 h after intravenous injection of Cy5-5-FU@HFn. (C) Fecal occult blood (FOB) scores were calculated from the FOB test results of BALB/c mice. (D) White blood cell (WBC), (E) red blood cell (RBC), and (F) platelet (PLT) counts in the peripheral blood of BALB/c mice were recorded after treatment with drugs. All the data are presented as the means ± SDs. ** P < 0.01