Fig. 11

Assessment of the protective effect of MCEVs on UC. (A) Schematic illustration of the establishment of a DSS-induced UC model and therapeutic strategies of MCEVs. (B) Body weight change chart of control, DSS, DSS + MCEVs 15 mg/kg, and DSS + MCEVs 30 mg/kg four groups of mice during 8 days (n = 6). (C) The Disease Activity Index (DAI) was recorded every day. (D) Representative images of the colon on day 8. (E) Comparison of colon length of four groups on day 8. (F) Comparison of spleen index of four groups on day 8. (G) Representative endoscopic images of four groups of mice on day 8. (H) Histological assessment of the mid-colon sections using H&E staining. (I) Alcian blue staining of the mid-colon sections to evaluate mucin secretion. (J) qRT-PCR to evaluate the transcription level of inflammatory cytokines. (I: DSS + MCEVs 15 mg/kg, II: DSS + MCEVs 30 mg/kg). Data were shown as mean ± SD. n ≥ 3, *: P < 0.05, **: P < 0.01, ***: P < 0.001, ns: P > 0.05, indicating no significance