Fig. 7
From: Extracellular particles: emerging insights into central nervous system diseases
EPs contribute to local and systemic crosstalk after Stroke. Neuron-derived EVs selectively enrich specific non-coding RNAs under hypoxia induction, and these EVs may serve as diagnostic biomarkers. Additionally, reactive microglia and astrocytes promote OPC differentiation and axon repair through EVs. Similarly, endothelium-derived microvesicles can also protect neurons from survival after stroke. MVB: multivesicular bodies; OPC: oligodendrocyte precursor cell; FUS: fused in sarcoma; tmTNF: transmembrane tumor necrosis factor; PrP-c1: prion protein C1 fragment; TUBB: β-tubulin (Figure created with BioRender)