Fig. 2

Targeted delivery of MVs in atherosclerotic mice. (A) Schematic representation of the preparation and imaging of atherosclerotic mice. (B) Representative ex vivo NIRF images of various tissues at different time points after tail vein injection of ICG or MVs@ICG. (C) Representative ex vivo NIRF images and oil red O staining of aortic tissues at different time points after tail vein injection of ICG or MVs@ICG. (D) HE staining and oil red O staining of atherosclerotic lesions and fluorescence images showing the accumulation of ICG in the atherosclerotic plaques of ApoE^−/− mice injected with ICG or MVs@ICG. (E) Immunofluorescence staining of atherosclerotic lesions after tail vein injection of MVs@ICG; nuclei and macrophages were stained with DAPI and FITC-labelled F4/80, respectively. (n = 3, scale bar = 200 μm)