Fig. 7
(a) Infrared thermal images and (b) temperature elevations in the tumors of 4T1 tumor-bearing mice treated with PBS or CAC NPs during 5 min irradiation (1064 nm, 0.75 W/cm2) at 12 h. (c) Representative tumor photographs after treatment with PBS, CAC NPs, and CAC + Laser at predetermined time intervals after different treatments. (10 mg/kg 200 µL) (d) Tumor volume changes of different groups during treatment, n = 5. (e) Corresponding tumor weight of different groups during treatment, n = 5. (f) The body weight changes of tumor-bearing mice with various treatments over 14 days, n = 5. (g) Survival rates of tumor-bearing mice with various treatments, n = 5. (h) DHE staining of mouse tumors after 14 days of different treatment to detecting ROS content. Scale bar: 100 μm. (i) Immunohistochemistry analysis (HSP70) analysis of mouse tumors after 14 days of different treatment. Scale bar: 25 μm. *p < 0.05, **p < 0.01, ***p < 0.001