Fig. 5
Nanotherapeutics-integrated microneedles to treat various skin injuries. (A) CSMN@TA-Mg/LDEV can dynamically modulate the microecology at the wound site [67]. Copyright 2024, Wiley-VCH. (B) Dual-module MN generates O2 and delivers miRNA-mDTC NPs and DFO for each stage of diabetic wound [70]. Copyright 2024, Wiley‐VCH. (C) The MN deliver COL1A1-EVs to improve photoaging skin [75]. Copyright 2023, Nature. (D) MN-mediated MOFs induce ferroptosis to treat HS [80]. Copyright 2023, Wiley‐VCH. (E) The nonlinear design of the MN arrays to treat skin diseases at varying skin depths [26]. Copyright 2024, Wiley‐VCH