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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Erythrocyte membrane camouflaged celastrol and bilirubin self-assembly for rheumatoid arthritis immunotherapy based on STING inhibition and RONS clearance

Fig. 5

Regulation and mechanism of M2 macrophage polarization by HA-RM-Cel-BR in vitro. Flow cytometry analysis of CD86 and CD206 expression levels (a) and relative expression of M2 macrophages (b) after different treatments. ELISA assay quantification of IL-10 (c), TNF-α (e), and IL-6 (f) expression levels in different formulation groups. (d) Protein expression levels of STING in RAW 264.7 cells after treatment with different formulations. Protein expression levels of p-I𝜅B𝛼, I𝜅B𝛼 (g), p-p65, and p65 (h) in RAW 264.7 cells after treatment with different formulations. (i) Protein expression levels of Nrf-2, Keap1, and HO-1 in RAW 264.7 cells after treatment with different formulations. (j) Mechanism diagram of HA-RM-Cel-BR regulates macrophage polarization. Data are presented as mean ± SD (n = 3). *P < 0.05, **P < 0.01, and ***P < 0.001

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Journal of Nanobiotechnology

ISSN: 1477-3155

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