Fig. 6

Transcriptomic analysis of macrophage immunomodulation by HA-RM-Cel-BR. (a) Volcano plot of differentially expressed genes in RAW 264.7 between PBS and HA-RM-Cel-BR treated groups. (b) Principal component analysis (PCA) in RAW 264.7 between PBS group and HA-RM-Cel-BR treatment. (c) Pearson’s correlation coefficient r to verify sample reproducibility. (d) Heat map of the DEGs related to inflammation and immune regulation. (e) GO enrichment term analysed for its effect on macrophage function. (f) KEGG pathway enrichment analysis (P < 0.05)