Enhanced therapeutic effects of all-trans retinoic acid nanostructured lipid carrier composite gel drug delivery system for alopecia areata

Table 1 Fitting analysis of ATRA in different formulations

Formulations	Model	Regression equation	R²
ATRA	Zero-order	Q = 22t + 19.28	0.7135
	First-order	Q = 96.8367(1-e^− 1.06t),	0.9998
	Higuchi	Q = 49.88t^1/2+3.7	0.3727
ATRA cream	Zero-order	Q = 2.9t + 42.35	0.4023
	First-order	Q = 87.8806(1-e^− 0.71t)	0.9722
	Higuchi	Q = 18.32t^1/2+23.10	0.7382
ATRA-NLC	Zero-order	Q = 1.7t + 30.34	0.6102
	First-order	Q = 88.9106(1-e^− 0.18t)	0.9737
	Higuchi	Q = 14.15t^1/2+11.83	0.8854
ATRA-NLC-Gel	Zero-order	Q = 1.9 t + 17.35	0.7450
	First-order	Q = 91.9462(1-e^− 0.09t)	0.9899
	Higuchi	Q = 14.86t^1/2-0.8163	0.9353

ISSN: 1477-3155