Fig. 3

Strategies for tissues targeted delivery Using Nanotechnolgy in obesity therapy. (Created in https://BioRender.com). This Figure illustrates cutting-edge strategies that leverage nanotechnology to achieve tissue-specific drug delivery in obesity treatment. The figure demonstrates how lipid-based and polymeric nanoparticles can be engineered with adipose-specific ligands to ensure targeted delivery to adipose tissue, liver, or muscle. It also shows how thermos-responsive nanoparticles can be triggered by body temperature to release their therapeutic contents precisely within adipose tissue. Additionally, the use of microneedle systems is presented as a non-invasive method to deliver anti-obesity agents transdermally, enhancing drug retention and minimizing discomfort. Gene delivery applications using nanocarriers such as siRNA-loaded nanoparticles—are depicted for their ability to modulate obesity-related genes at the molecular level. Furthermore, the figure outlines dual-delivery platforms that co-administer appetite suppressants and anti-inflammatory agents for synergistic therapeutic effects. Finally, stimuli-responsive nanoparticles are highlighted for their ability to release drugs selectively in response to environmental changes such as pH, temperature, or enzymatic activity, offering precise and personalized therapeutic outcomes in obesity management