Fig. 5

(A) PCA of the differentially expressed genes in the CS@Fc and CS@Fc + NIR groups. (B) Volcano plot of the differentially expressed genes in the CS@Fc and CS@Fc + NIR groups (FC ≥ 1.0, p < 0.05). (C) Heat map of genes in the CS@Fc and CS@Fc + NIR groups. Quantitative analysis of the expression of (D) GPX4 and (E) SLC7A11 expression with various treatments in KYSE70 cells and (F) western blot assay. (G) HMGB1 release and (H) ATP secretion from KYSE70 cells after various treatments. (I) Confocal fluorescence quantification and (J) images of CRT in KYSE70 cells after various treatments. Scale bar: 150 μm