Fig. 7

(a) Temperature change of Au-Pt@ur NPs after 5 cycles (on/off) irradiation by 808-nm laser (1.5 W·cm^− 2). (b) Heating/cooling curves for Au-Pt@ur NPs and PBS (808-nm laser, 1.5 W·cm^− 2). (c-d) Infrared thermal mapping images, and corresponding temperature profiles of tumor regions after irradiated with an 808-nm laser (1.5 W·cm^− 2) for different times (0 ~ 10 min) at 2 h-intravesical instillation of Au-Pt@ur NPs or PBS. (e) Anticancer efficacy of different intravesical therapies, illustrated by bioluminescence imaging with luciferase-luciferin pairs. (f) In vivo bioluminescence intensity curves of orthotopic BCa in the corresponding groups in panel (e). (g) Averaged body weight of mice in the corresponding groups in panel (e). (h) Histopathological analysis of the representative bladders after the completion of intravesical therapies from the corresponding mice in panel (e) by H&E staining, scar bar: 100 μm